Gleason grading of prostate carcinoma in needle biopsies vs. radical prostatectomy specimens

The Gleason grading system for prostatic carcinoma is the dominant method used around the world in research and in daily practice. It is based on glandular architecture. The grading system should be applied to all prostatic tissue samples, including needle core biopsies and radical prostatectomy spe...

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Bibliographic Details
Published inAnalytical and quantitative cytology and histology Vol. 27; no. 3; p. 125
Main Authors Mazzucchelli, Roberta, Barbisan, Francesca, Tarquini, Lucia M, Filosa, Alessandra, Campanini, Nicoletta, Galosi, Andrea B
Format Journal Article
LanguageEnglish
Published United States 01.06.2005
Subjects
Adenocarcinoma - classification
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Biopsy
Biopsy, Needle
Humans
Male
Prognosis
Prostate - pathology
Prostate - surgery
Prostatectomy
Prostatic Neoplasms - classification
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
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Summary:The Gleason grading system for prostatic carcinoma is the dominant method used around the world in research and in daily practice. It is based on glandular architecture. The grading system should be applied to all prostatic tissue samples, including needle core biopsies and radical prostatectomy specimens. Its prognostic value was tested in a large population with long-term follow-up that included use of survival as an end point. The Gleason grading system shows a reasonable degree of correlation between biopsy and radical prostatectomy specimens. Several sources of discrepancy between these 2 types of specimen have been identified. Further educational endeavors are needed to arrive at a greater consensus and accuracy in the use of the Gleason system.
ISSN:0884-6812