The association of ICAM E469K with cardiovascular characteristics of acromegaly

It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients. We included 41 patients with acromegal...

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Published inEuropean review for medical and pharmacological sciences Vol. 19; no. 9; p. 1673
Main Authors Oguz, E, Tabur, S, Akbas, H, Duzen, I V, Karabag, H, Akkafa, F, Ozkaya, M, Alasehirli, B
Format Journal Article
LanguageEnglish
Published Italy 2015
Subjects
Acromegaly - complications
Acromegaly - genetics
Adult
Blood Pressure
Case-Control Studies
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Female
Humans
Intercellular Adhesion Molecule-1 - genetics
Male
Middle Aged
Polymorphism, Genetic
Risk Factors
Triglycerides - blood
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Summary:It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients. We included 41 patients with acromegaly and 65 healthy subjects with similar age and sex to the study. Fasting plasma glucose (FPG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG) were analyzed. Genotyping was made by polymerase chain reaction-restriction fragment length polymorphism. The frequency of genotype and allel ICAM-1 E469K was not significantly different between control and patients (p > 0.05). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG levels were significantly higher, and HDL-C was significantly lower in patients with KK genotypes compared to patients with EE genotype in acromegaly group (p < 0.05). This is the first study to investigate the role of ICAM gene polymorphism in acromegaly and its cardiovascular characteristics. ICAM E469K may not be a risk factor for the acromegaly in Turkish population but may be associated with hypertension, higher FPG and lower HDL-C in acromegalic patients.
ISSN:2284-0729