Functional eicosanoid test and typing (FET) in acetylsalicylic acid intolerant patients with urticaria

One of the common side effects of acetylsalicylic acid (ASA) is the induction of pseudoallergic reactions that range from urticarial wheals to anaphylactic shock. At present there is no reliable detection method available for the diagnosis of ASA-hypersensitivity and its relation to clinical symptom...

Full description

Saved in:
Bibliographic Details
Published inJournal of physiology and pharmacology : an official journal of the Polish Physiological Society Vol. 57 Suppl 12; p. 35
Main Authors Velten, F W, Bayerl, C, Baenkler, H W, Schaefer, D
Format Journal Article
LanguageEnglish
Published Poland 01.12.2006
Subjects
Adult
Aged
Anaphylaxis - chemically induced
Anaphylaxis - diagnosis
Angioedema - chemically induced
Angioedema - diagnosis
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Aspirin - adverse effects
Case-Control Studies
Drug Hypersensitivity - diagnosis
Eicosanoids - analysis
Eicosanoids - classification
Eicosanoids - metabolism
Female
Humans
Immunoenzyme Techniques - methods
Leukotrienes - analysis
Leukotrienes - metabolism
Male
Middle Aged
Prostaglandins - analysis
Prostaglandins - metabolism
Urticaria - chemically induced
Urticaria - diagnosis
Online AccessGet more information

Cover

More Information
Summary:One of the common side effects of acetylsalicylic acid (ASA) is the induction of pseudoallergic reactions that range from urticarial wheals to anaphylactic shock. At present there is no reliable detection method available for the diagnosis of ASA-hypersensitivity and its relation to clinical symptoms. The purpose of the present study was to evaluate the functional eicosanoid typing (FET) score taking into account several parameters of the equilibrium between prostaglandins (PG) and peptido-leukotriens (pLT). A total eicosanoid pattern score (TEP) ranging from 0.0 to 3.0, was defined that exhibited significant differences (p <or= 0.001) between ASA-intolerant patients and healthy subjects. In addition to the differentiation of both groups at a TEP cut-off value of 1.0, the increasing TEP values correlated with an increasing severity of clinical symptoms in ASA-intolerant patients. We conclude that the FET has the potential for the safe and reliable detection of ASA-intolerance and, probably, other eicosanoid-related pseudoallergic reactions.
ISSN:1899-1505