Improvement of survival in patients with melanoma and non-melanoma skin cancers compared to patients without double cutaneous malignancies

• Published in: European review for medical and pharmacological sciences Vol. 19; no. 9; p. 1640
• Main Authors: Bottoni, U, Paolino, G, Didona, D, Corsetti, P, Clerico, R, Cantisani, C, Richetta, A G, Arcidiacono, V, Scali, E, Pranteda, G, Calvieri, S
• Format: Journal Article
• Language: English
• Published: Italy 2015
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell - mortality; Carcinoma, Basal Cell - pathology; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Case-Control Studies; Disease-Free Survival; Female; Humans; Italy; Male; Melanoma - mortality; Melanoma - pathology; Melanoma, Cutaneous Malignant; Middle Aged; Skin Neoplasms - mortality; Skin Neoplasms - pathology
• ISSN: 2284-0729

The worldwide incidence of cutaneous malignant melanoma (MM) has been rising steadily over the past 30 years. At the same time non-melanoma skin cancers (NMSC) are the most prevalent type of cancer in United States and Europe. Up to date, no paper has explored the influence on the general survival in patients with MM and NMSC. We decided to perform a study with the aim to evaluate the different survival in patients with MM-NMSC compared to control patients (MM-CTRL). To evaluate prognosis in both groups, we analyzed disease-free survival (DFS) and overall survival (OS).Kaplan-Meier product was performed for the survival analysis. Median DFS was 73 months in group and 72 months in MM-CTRL patients (p = 0.4); while, median OS was 74.2 months in MM-NMSC patients and 63.1 in MM-CTRL (p < 0.001). Also at Odds-Ratio (OR), the statistical significance was maintained (p < 0.007) with a better prognostic value for MM-NMSC. Among group patients, the ones with a basal cell carcinoma showed a batter behavior, than the ones with squamous cell carcinoma (p = 0.01). Patients with MM-NMSC showed a better survival than MM-CTRL patients (p < 0.001). The causes of this improved survival are still unknown; probably the endogenous immune response can play a pivotal role in this class of patients. However, further studies are necessary to better understand this phenomenon, not yet explored in literature.