Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III

In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into...

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Bibliographic Details
Published inAnnals of surgery Vol. 209; no. 3; pp. 307 - 311
Main Authors Bauer, T, Vennits, B, Holm, B, Hahn-Pedersen, J, Lysen, D, Galatius, H, Kristensen, E S, Graversen, P, Wilhelmsen, F, Skjoldborg, H
Format Journal Article
LanguageEnglish
Published United States 01.03.1989
Subjects
Abdomen
Abscess - prevention & control
Acute Disease
Adult
Appendectomy
Appendicitis - surgery
Cefoxitin - therapeutic use
Denmark
Female
Humans
Male
Multicenter Studies as Topic
Premedication
Prospective Studies
Random Allocation
Surgical Wound Infection - prevention & control
Denmark
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Summary:In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-198903000-00010