The immune response to heterologous red cells in mice. II. Antibody formation to red cells from species taxonomically related to sheep or mouse

An attempt was made to establish the relative immunogenicity of various heterologous erythrocytes in the mouse. The immune response to multispecies red cells was examined by zone centrifugation of the antibodies, and by studying cross-reactivity between the varioys erythrocytes, time-course of haema...

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Bibliographic Details
Published inImmunology Vol. 13; no. 6; pp. 585 - 595
Main Authors Dietrich, F M, Dukor, P
Format Journal Article
LanguageEnglish
Published England 01.12.1967
Subjects
Animals
Antibody Formation
Centrifugation, Zonal
Cricetinae
Cyclophosphamide - pharmacology
Erythrocytes - immunology
Gerbillinae
Goats
Hemagglutination - drug effects
Mercaptopurine - pharmacology
Mice
Sheep
Thioguanine - pharmacology
Trypsin - pharmacology
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Summary:An attempt was made to establish the relative immunogenicity of various heterologous erythrocytes in the mouse. The immune response to multispecies red cells was examined by zone centrifugation of the antibodies, and by studying cross-reactivity between the varioys erythrocytes, time-course of haemagglutinin formation, and finally, antigen dose—antibody response relationships. As compared to sheep erythrocytes, goat erythrocytes were found to have a greatly reduced agglutinability, which merely simulated a reduced immunogenicity. However, erythrocytes from gerbil and hamster proved to be genuinely weaker antigens in the mouse. For alkylating agents, anti-metabolites and anti-mitotic compounds the drug-sensitivity of the immune response to cells of different antigenicity was not altered.
ISSN:0019-2805
1365-2567