Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa

Human low density lipoproteins are metabolized by cultured human fibroblasts, through a specific metabolic pathway, which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein IgA coming from patients with myeloma, mixed hyperlipidaemia and xanthomatosis were introduce...

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Bibliographic Details
Published inClinical and experimental immunology Vol. 39; no. 2; pp. 455 - 460
Main Authors Baudet, M F, Dachet, C, Beaumont, J L
Format Journal Article
LanguageEnglish
Published England 01.02.1980
Subjects
Adult
Cells, Cultured
Cholesterol - biosynthesis
Female
Fibroblasts - metabolism
Humans
Hyperlipidemias - immunology
Immunoglobulin A - immunology
Immunoglobulin kappa-Chains - immunology
Lipoproteins, LDL - metabolism
Male
Middle Aged
Xanthomatosis - immunology
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Summary:Human low density lipoproteins are metabolized by cultured human fibroblasts, through a specific metabolic pathway, which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein IgA coming from patients with myeloma, mixed hyperlipidaemia and xanthomatosis were introduced into the system, we observed a decrease of the protein degradation of the LDL molecule, and a disappearance of the regulation of intracellular cholesterol synthesis. In the same system, an anti-lipoprotein IgA from a case of myeloma with mixed hyperlipidaemia, but without xanthomatosis, or control IgG and IgA were inactive and did not modify the LDL pathway.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0009-9104
1365-2249