The effect of cyclosporin A on peripheral blood T cell subpopulations in renal allografts

Treatment with cyclosporin A (CyA) produces a reversal of the normal ratio of OKT4+ (inducer type) to OKT84 (suppressor-cytotoxic type) cells so that renal allograft recipients on CyA alone develop a four-fold increase in the absolute number of circulating OKT8 positive cells. Conventional immunosup...

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Bibliographic Details
Published inClinical and experimental immunology Vol. 47; no. 2; pp. 445 - 448
Main Authors Sweny, P, Tidman, N
Format Journal Article
LanguageEnglish
Published England 01.02.1982
Subjects
Azathioprine - therapeutic use
Cyclosporins - therapeutic use
Humans
Kidney Transplantation
Leukocyte Count
Prednisolone - therapeutic use
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - drug effects
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Summary:Treatment with cyclosporin A (CyA) produces a reversal of the normal ratio of OKT4+ (inducer type) to OKT84 (suppressor-cytotoxic type) cells so that renal allograft recipients on CyA alone develop a four-fold increase in the absolute number of circulating OKT8 positive cells. Conventional immunosuppression with azathioprine and prednisolone reduces both populations of T cells without altering the ratio of OKT4+ to OKT8+ cells. This effect of CyA may help to explain its action as an immunosuppressive agent.
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ISSN:0009-9104
1365-2249