Karyometry and histometry of renal-cell carcinoma

In an attempt to more objectively predict the outcome of renal cancers, karyometric and histometric studies were performed using an interactive computer-based system for the quantitative analysis of tissue sections. Analysis showed a significant relationship between patient survival and metastases a...

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Bibliographic Details
Published inAnalytical and quantitative cytology and histology Vol. 9; no. 2; p. 182
Main Authors Bibbo, M, Galera-Davidson, H, Dytch, H E, Gonzalez de Chaves, J, Lopez-Garrido, J, Bartels, P H, Wied, G L
Format Journal Article
LanguageEnglish
Published United States 01.05.1987
Subjects
Adult
Aged
Carcinoma, Renal Cell - pathology
Cell Nucleus - pathology
Humans
Karyometry
Kidney Neoplasms - pathology
Middle Aged
Mitosis
Neoplasm Metastasis
Prognosis
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Summary:In an attempt to more objectively predict the outcome of renal cancers, karyometric and histometric studies were performed using an interactive computer-based system for the quantitative analysis of tissue sections. Analysis showed a significant relationship between patient survival and metastases and the histometric parameters of nuclear elongation, nuclear crowding and mitotic density, as well as tumor grade. Patients who died tended to have a high mitotic density, elongated and crowded nuclei and high-grade tumors. Ploidy showed no significant correlation with prognosis while nuclear elongation and crowding did. Differences in histologic grade were significantly associated with several histometric variables, including nuclear area, shape, crowding, elongation and mitotic density.
ISSN:0884-6812