Interstitial foam cells in the nephrotic syndrome belong to the monocyte/macrophage lineage

Interstitial foam cells are occasionally seen in patients with the nephrotic syndrome. In a group of patients with the nephrotic syndrome we were able to demonstrate that these cells express markers characteristic of the monocyte/macrophage lineage. Their presence was related to the previous duratio...

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Published inProceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Vol. 21; p. 666
Main Authors Nolasco, F, Cameron, J S, Reuben, R, Hartley, B, Carvalho, F, Coelho, R A
Format Journal Article
LanguageEnglish
Published England 1985
Subjects
Adult
Foam Cells - immunology
Foam Cells - pathology
Histocompatibility Antigens Class II
HLA-DR Antigens
Humans
Macrophages - pathology
Monocytes - pathology
Nephrotic Syndrome - immunology
Nephrotic Syndrome - pathology
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Summary:Interstitial foam cells are occasionally seen in patients with the nephrotic syndrome. In a group of patients with the nephrotic syndrome we were able to demonstrate that these cells express markers characteristic of the monocyte/macrophage lineage. Their presence was related to the previous duration of proteinuria, but they had no apparent influence on the subsequent evolution of renal function. The mechanisms leading to their presence are unknown.