Distal tubular sodium and water resorption in man

It is possible to quantitatively estimate Na and water transport by each segment of the human nephron during maximal water diuresis (MWD) with a newly developed technique. The present study describes a new development whereby Na reabsorption by the ascending limb of Henle's Loop can be measured...

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Bibliographic Details
Published inProceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Vol. 21; p. 738
Main Authors Bartoli, E, Faedda, R, Satta, A, Sanna, M, Branca, G F
Format Journal Article
LanguageEnglish
Published England 1985
Subjects
Absorption
Adult
Biological Transport, Active
Body Water - metabolism
Humans
Kidney Tubules - metabolism
Kidney Tubules, Distal - metabolism
Loop of Henle - metabolism
Sodium - metabolism
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Summary:It is possible to quantitatively estimate Na and water transport by each segment of the human nephron during maximal water diuresis (MWD) with a newly developed technique. The present study describes a new development whereby Na reabsorption by the ascending limb of Henle's Loop can be measured during a test of maximal antidiuresis (TMA) and compared with that obtained in separate experiments during MWD. In experiments performed on eight subjects, Henle's Loop reabsorption, expressed as equivalent volume of solute-free water generated, was 23.9 +/- 3.7 during MWD, 24.5 +/- 2.3 ml/min/100 ml GFR in TMA, p greater than 0.05; r = 0.68, p less than 0.05. Thus, our new method is reproducible and theoretically correct.