Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance

Peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that play critical roles in the regulation of energy metabolism. Synthetic agonists for these receptors are used in the treatment of type 2 diabetes mellitus and dyslipidemia. Current data linki...

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Bibliographic Details
Published inCurrent opinion in investigational drugs (London, England : 2000) Vol. 5; no. 10; p. 1045
Main Authors Patsouris, David, Müller, Michael, Kersten, Sander
Format Journal Article
LanguageEnglish
Published England 01.10.2004
Subjects
Animals
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin Resistance
Ligands
Peroxisome Proliferator-Activated Receptors - agonists
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Summary:Peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that play critical roles in the regulation of energy metabolism. Synthetic agonists for these receptors are used in the treatment of type 2 diabetes mellitus and dyslipidemia. Current data linking PPAR and/or PPAR ligands with the treatment of insulin resistance will be critically reviewed, with the focus on important advances over the past year.
ISSN:1472-4472