The gene(s) controlling the synthesis of C1 esterase inhibitor is not linked to the genes of the HLA system and is not on the 6th chromosome

Certain genes of the complement system are carried by the 6th chromosome and are sometimes linked to particular genes of the HLA system. This study shows that in 15 patients suffering from hereditary angioneurotic oedema the gene(s) controlling the synthesis of C1 esterase inhibitor is not linked to...

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Bibliographic Details
Published inBiomedicine / [publiee pour l'A.A.I.C.I.G.] Vol. 29; no. 7; p. 248
Main Authors Goasguen, J, Fauchet, R, Guerin, D, Genetet, B, Brecy, H, Ollier, M P, Hartmann, L
Format Journal Article
LanguageEnglish
Published France 01.11.1978
Subjects
Angioedema - genetics
Chromosome Mapping
Chromosomes, Human, 6-12 and X
Complement C1 Inactivator Proteins - genetics
Female
Genes, Regulator
Genetic Linkage
HLA Antigens - analysis
HLA Antigens - genetics
Humans
Male
Pedigree
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Summary:Certain genes of the complement system are carried by the 6th chromosome and are sometimes linked to particular genes of the HLA system. This study shows that in 15 patients suffering from hereditary angioneurotic oedema the gene(s) controlling the synthesis of C1 esterase inhibitor is not linked to the genes HLA-A or B and is not on the 6th chromosome.
ISSN:0300-0893