Allopurinol-induced hypersensitivity syndrome resulting in death

The present report describes the case of a 67-year-old patient who developed an allopurinol-induced hypersensitivity syndrome (AHS) with toxic epidermal necrolysis and subsequently died of septic multiorgan failure. Considering the increasing prescription rate of allopurinol, the present case report...

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Bibliographic Details
Published inMedizinische Klinik (München. 1983) Vol. 105; no. 4; p. 262
Main Authors Laurisch, Sören, Jaedtke, Maren, Demir, Reyhan, Sorrentino, Sajoscha A, Kielstein, Jan T, Rennekampff, Hans-Oliver, Vogt, Peter M, Meyer, Gerd P, Fuchs, Martin, Klein, Gunnar, Drexler, Hartmut, Schieffer, Bernhard, Napp, L Christian
Format Journal Article
LanguageGerman
Published Germany 01.04.2010
Subjects
Aged
Allopurinol - toxicity
Diagnosis, Differential
Drug Hypersensitivity - diagnosis
Drug Hypersensitivity - etiology
Drug Hypersensitivity - therapy
Fatal Outcome
Gout - drug therapy
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - therapy
Male
Multiple Organ Failure - chemically induced
Multiple Organ Failure - diagnosis
Multiple Organ Failure - therapy
Recurrence
Stevens-Johnson Syndrome - diagnosis
Stevens-Johnson Syndrome - etiology
Stevens-Johnson Syndrome - therapy
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Summary:The present report describes the case of a 67-year-old patient who developed an allopurinol-induced hypersensitivity syndrome (AHS) with toxic epidermal necrolysis and subsequently died of septic multiorgan failure. Considering the increasing prescription rate of allopurinol, the present case report intends to demonstrate the underestimated threat of AHS.
ISSN:1615-6722
DOI:10.1007/s00063-010-1037-3