Relationship between serum omentin-1 level and bone mineral density in girls with anorexia nervosa

• Published in: Journal of endocrinological investigation Vol. 36; no. 3; pp. 190 - 194
• Main Authors: Guo, L.-J., Jiang, T.-J., Liao, L., Liu, H., He, H.-B.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2013
• Subjects: Adiponectin - blood; Adolescent; Anorexia Nervosa - blood; Anorexia Nervosa - metabolism; Anorexia Nervosa - physiopathology; Biomarkers - blood; Body Composition - physiology; Body Mass Index; Bone Density - physiology; Bone Remodeling - physiology; Case-Control Studies; Cytokines - blood; Endocrinology; Female; GPI-Linked Proteins - blood; Humans; Lectins - blood; Leptin - blood; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Regression Analysis; anorexia nervosa; bone mineral density; Omentin-1
• ISSN: 0391-4097; 1720-8386
• DOI: 10.3275/8458

Background: Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Omentin-1, the main circulating adipocytokine, plays an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown. Methods: Serum omentin-1, bone turnover biochemical markers, and BMD were determined in 26 girls with AN and 24 healthy girls (15–18 years old). Results: Omentin-1 levels increased in AN subjects, and the differences became greater after controlling for fat mass. Omentin-1 was negatively correlated with BMD. In the multiple linear stepwise regression analysis, omentin-1, body mass index and lean mass, but not fat mass, were independent predictors of BMD for the combined group. Significant negative correlations were found between omentin-1 and bone-specific alkaline phosphatase, bone cross-linked N-telopeptides of type I collagen. Omentin-1 was also independently associated with BMD and bone turnover markers in the AN and control groups considered separately. Conclusions: Omentin-1 was an independent predictor of BMD in adolescents with AN, and negatively correlated with bone turnover markers. This suggested that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in girls with AN.