Identification of blood microRNAs associated to Parkinsonǐs disease

The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-on...

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Bibliographic Details
Published inJournal of biotechnology Vol. 152; no. 3; pp. 96 - 101
Main Authors MARGIS, Regina, MARGIS, Rogerio, RIEDER, Carlos R. M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 20.03.2011
Subjects
Aged
Biological and medical sciences
Biotechnology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Gene Expression Regulation
Humans
Male
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Parkinson Disease - blood
Parkinson Disease - genetics
Gene silencing
MicroRNA
Parkinson's disease
Micro RNA
Parkinson disease
Neurodegenerative disease
Identification
Molecular marker
RT-qPCR
Blood
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Summary:The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0168-1656
1873-4863
1873-4863
DOI:10.1016/j.jbiotec.2011.01.023