HDL apolipoprotein A-I and HDL apolipoprotein A-II concentrations in male company employees in Westphalia aged 40 years and older

The major structural components of high density lipoproteins were determined in the sera of 638 male employees aged 40 years and older. It was demonstrated that the HDL apolipoprotein A-I/HDL cholesterol ratio as well as the HDL apolipoprotein A-II/HDL cholesterol ratio are similarly correlated to a...

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Bibliographic Details
Published inJournal of clinical chemistry and clinical biochemistry Vol. 24; no. 9; p. 627
Main Authors Schriewer, H, Emke, F, Funke, H, Schulte, H, Assmann, G
Format Journal Article
LanguageEnglish
Published Germany 01.09.1986
Subjects
Adult
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins A - blood
Arteriosclerosis - etiology
Cholesterol, HDL - blood
Germany, West
Humans
Lipoproteins, HDL - blood
Male
Prospective Studies
Risk
Germany, West
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Summary:The major structural components of high density lipoproteins were determined in the sera of 638 male employees aged 40 years and older. It was demonstrated that the HDL apolipoprotein A-I/HDL cholesterol ratio as well as the HDL apolipoprotein A-II/HDL cholesterol ratio are similarly correlated to a cumulative score of established risk factors for atherosclerosis. Most important, however, is the finding that the correlation of these ratios to the risk factor rating of atherosclerosis is found in subgroups with normal or elevated HDL cholesterol values. Furthermore, it is shown that the relative content of apolipoproteins A-I and A-II in individual HDL is partly dependent on the plasma concentration of HDL cholesterol and triglycerides. It is concluded that HDL composition may have an additional predictive significance for the development of atherosclerosis.
ISSN:0340-076X