Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and beta-nitrostyrenes

An efficient synthesis of 2H-3-nitrothiochromenes via a cascade reaction was established. Starting from commercially available o-bromobenzaldehydes and beta-nitrostyrenes with sodium sulfide nonahydrate as an inexpensive sulfur source, various substituted thiochromenes were synthesized with high fun...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 17; no. 26; pp. 6355 - 6358
Main Authors Thi Thu Huong Le, Youhei, Chitose, Quy Hien Le, Thanh Binh Nguyen, Dinh Hung Mac
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.07.2019
Royal Society of Chemistry
Subjects
Cascade chemical reactions
Chemistry
Chemistry, Organic
Crystallography
Functional groups
Physical Sciences
Science & Technology
Sodium
Sodium sulfide
Sulfide
Sulfides
Sulfur
Transition metals
DESIGN
ENANTIOSELECTIVE SYNTHESIS
ANALOGS
THIOCHROMENES
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Summary:An efficient synthesis of 2H-3-nitrothiochromenes via a cascade reaction was established. Starting from commercially available o-bromobenzaldehydes and beta-nitrostyrenes with sodium sulfide nonahydrate as an inexpensive sulfur source, various substituted thiochromenes were synthesized with high functional group tolerance without any added transition metal catalyst or additive.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob01060b