Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans

A 1.8-kb cDNA encoding portion of a novel collagenous chain was isolated from a human rhabdomyosarcoma cell line by cross-hybridization using a chicken type V collagen probe. Sequence analysis suggests that this chain belongs to the recently discovered group of collagens, termed the FACIT class of m...

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Published inGenomics (San Diego, Calif.) Vol. 13; no. 3; pp. 884 - 886
Main Authors Yoshioka, H, Zhang, H, Ramirez, F, Mattei, M G, Moradi-Ameli, M, van der Rest, M, Gordon, M K
Format Journal Article
LanguageEnglish
Published United States 01.07.1992
Subjects
Amino Acid Sequence
Base Sequence
chromosome 6
Chromosomes, Human, Pair 6
collagen
Collagen - classification
Collagen - genetics
DNA - genetics
DS6228E locus
Humans
loci
man
Molecular Sequence Data
Multigene Family
Sequence Homology, Nucleic Acid
type alpha 1
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Summary:A 1.8-kb cDNA encoding portion of a novel collagenous chain was isolated from a human rhabdomyosarcoma cell line by cross-hybridization using a chicken type V collagen probe. Sequence analysis suggests that this chain belongs to the recently discovered group of collagens, termed the FACIT class of macromolecules. This cDNA was used to locate the corresponding gene (D6S228E) to chromosome 6, notably at position 6q12-q14. Interestingly, within this region of human chromosome 6 residues the alpha 1 (IX) collagen gene (COL9A1), a member of the FACIT group.
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ISSN:0888-7543
DOI:10.1016/0888-7543(92)90176-S