Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment

• Published in: Nutrition journal Vol. 14; p. 112
• Main Authors: Khattab, May, Abi-Rashed, Christelle, Ghattas, Hala, Hlais, Sani, Obeid, Omar
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.10.2015
• Subjects: Adult; Blood Glucose; Cross-Over Studies; Glucose - administration & dosage; Glucose Tolerance Test - statistics & numerical data; Humans; Insulin - blood; Male; Nutrition; Phosphorus - administration & dosage; Phosphorus - blood; Postprandial Period; Reference Values; Young Adult
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/s12937-015-0101-5

Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated. Two cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n = 7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n = 8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion. In both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P < 0.05), insulin (P < 0.05), and insulin sensitivity index (p < 0.006), while P pre-ingestion failed to exert similar effect. This study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose.