Immunostimulating effect of interferon inducers

• Published in: Voprosy virusologiĭ Vol. 28; no. 4; p. 74
• Main Authors: Ershov, F I, Barinskiĭ, I F, Podcherniaeva, R Ia, Gribencha, S V, Popova, O M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.1983
• Subjects: Adjuvants, Immunologic - therapeutic use; Animals; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - prevention & control; Herpes Simplex - prevention & control; Influenza Vaccines - therapeutic use; Interferon Inducers - therapeutic use; Interferons - analysis; Mice; Orthomyxoviridae Infections - prevention & control; Poly C - therapeutic use; Poly G - therapeutic use; Rabies - prevention & control; Rabies Vaccines - therapeutic use; RNA, Double-Stranded - therapeutic use; Simplexvirus - immunology; Time Factors; Vaccines, Attenuated - therapeutic use; Viral Vaccines - immunology
• ISSN: 0507-4088

The effect of interferon inducers on the immune response to vaccination was determined. The prophylactic effect of interferon inducers in combination with vaccines was determined with regard to experimental influenza, the therapeutic effect with regard to rabies and tick-borne encephalitis. Despite the differences in the experimental design (administration of the inducers before, after, or together with vaccines), the additive or synergistic effect was regularly observed with a 2-6-fold increase in the level of protection of the animals infected with the appropriate viruses as compared with the use of vaccines or interferon inducers separately. The protective effect depends a lot on the concentration, site and time of inoculation of the preparations, multiplicity of infection, and some other conditions.