The MRL model: an invaluable tool in studies of autoimmunity-brain interactions

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 934; p. 277
• Main Author: Sakić, Boris
• Format: Journal Article
• Language: English
• Published: United States 2012
• Subjects: Animals; Autoimmune Diseases - immunology; Autoimmune Diseases - pathology; Autoimmunity; Brain - immunology; Brain - pathology; Disease Models, Animal; Humans; Immune System - immunology; Immune System - pathology; Mice; Mice, Inbred MRL lpr - immunology

The link between systemic autoimmunity, brain pathology, and aberrant behavior is still largely unexplored field of biomedical science. Accumulating evidence points to causal relationships between immune factors, neurodegeneration, and neuropsychiatric manifestations. By documenting autoimmunity-ass...