The MRL model: an invaluable tool in studies of autoimmunity-brain interactions

The link between systemic autoimmunity, brain pathology, and aberrant behavior is still largely unexplored field of biomedical science. Accumulating evidence points to causal relationships between immune factors, neurodegeneration, and neuropsychiatric manifestations. By documenting autoimmunity-ass...

Full description

Saved in:
Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 934; p. 277
Main Author Sakić, Boris
Format Journal Article
LanguageEnglish
Published United States 2012
Subjects
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity
Brain - immunology
Brain - pathology
Disease Models, Animal
Humans
Immune System - immunology
Immune System - pathology
Mice
Mice, Inbred MRL lpr - immunology
Online AccessGet more information

Cover

More Information
Summary:The link between systemic autoimmunity, brain pathology, and aberrant behavior is still largely unexplored field of biomedical science. Accumulating evidence points to causal relationships between immune factors, neurodegeneration, and neuropsychiatric manifestations. By documenting autoimmunity-associated neuronal degeneration and cytotoxicity of the cerebrospinal fluid from disease-affected subjects, the murine MRL model had shown high validity in revealing principal pathogenic circuits. In addition, unlike any other autoimmune strain, MRL mice produce antibodies commonly found in patients suffering from lupus and other autoimmune disorders. This review highlights importance of the MRL model as an indispensible preparation in understanding the links between immune system and brain function.
ISSN:1940-6029
DOI:10.1007/978-1-62703-071-7_14