Left Ventricular Pressure Volume Assessment Using Carotid Artery Access in the Rat

Left ventricular (LV) catheterization with either a pressure catheter or pressure-volume catheter provides a means to measure cardiac function, an important endpoint in many studies including cardiac gene therapy. While the catheter can be inserted directly into the heart using a surgical approach,...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2573; p. 305
Main Authors Mavropoulos, Spyros A, Ishikawa, Kiyotake
Format Journal Article
LanguageEnglish
Published United States 2022
Subjects
Animals
Cardiac Catheterization - methods
Carotid Arteries
Heart - physiology
Rats
Ventricular Function, Left - physiology
Ventricular Pressure
Pressure catheter
Cardiac function
Carotid artery catheterization
Left ventricle
PV loop
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Summary:Left ventricular (LV) catheterization with either a pressure catheter or pressure-volume catheter provides a means to measure cardiac function, an important endpoint in many studies including cardiac gene therapy. While the catheter can be inserted directly into the heart using a surgical approach, utilizing the carotid artery for access has the advantage of being a closed-chest procedure. This negates the need for intubation, prevents myocardial trauma, and preserves normal intrathoracic pressure, providing more accurate assessments of cardiac physiology parameters. We describe a protocol for obtaining carotid artery access and insertion of a pressure-volume catheter into the LV of rodents.
ISSN:1940-6029
DOI:10.1007/978-1-0716-2707-5_23