Capture and Release of Cancer Cells Through Smart Bioelectronics

Noninvasive collection of target cells such as circulating tumor cells (CTCs) is crucial for biology and medicine research. Conventional methods of cell collection are often complex, requiring either size-dependent sorting or invasive enzymatic reactions. Here, we show the development of a functiona...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2679; p. 305
Main Authors Saez, Janire, Garcia-Hernando, Maite, Savva, Achilleas, Owens, Roisin M, Benito-Lopez, Fernando, Basabe-Desmonts, Lourdes
Format Journal Article
LanguageEnglish
Published United States 2023
Subjects
Conducting polymers
Cancer cells
Bioelectronics
NIPAAm
Capture
Release
Electrochemical impedance spectroscopy
PEDOT:PSS
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Summary:Noninvasive collection of target cells such as circulating tumor cells (CTCs) is crucial for biology and medicine research. Conventional methods of cell collection are often complex, requiring either size-dependent sorting or invasive enzymatic reactions. Here, we show the development of a functional polymer film, which combines the thermoresponsive poly(N-isopropylacrylamide) and the conducting poly(3,4-ethylenedioxythiopene)/poly(styrene sulfonate), and its use for the capture and release of CTCs. When coated onto microfabricated gold electrodes, the proposed polymer films are capable of noninvasively capturing and controllably releasing cells while, at the same time, monitoring these processes with conventional electrical measurements.
ISSN:1940-6029
DOI:10.1007/978-1-0716-3271-0_21