Cytometry in High-Containment Laboratories

The emergence of new pathogens continues to fuel the need for advanced high-containment laboratories across the globe. Here we explore challenges and opportunities for integration of cytometry, a central technology for cell analysis, within high-containment laboratories. We review current applicatio...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2779; p. 425
Main Authors Cohen, Melanie, Laux, Julie, Douagi, Iyadh
Format Journal Article
LanguageEnglish
Published United States 2024
Subjects
Artificial Intelligence
Biomedical Research
Containment of Biohazards
Laboratories
Technology
High containment
Flow cytometry
Infectious sample
Multiomics
Cell sorting
CYTOF
Cell analysis
Biosafety
Cytometry
Infectious disease
Aerosols
Public health
Emerging pathogens
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Summary:The emergence of new pathogens continues to fuel the need for advanced high-containment laboratories across the globe. Here we explore challenges and opportunities for integration of cytometry, a central technology for cell analysis, within high-containment laboratories. We review current applications in infectious disease, vaccine research, and biosafety. Considerations specific to cytometry within high-containment laboratories, such as biosafety requirements, and sample containment strategies are also addressed. We further tour the landscape of emerging technologies, including combination of cytometry with other omics, the application of automation, and artificial intelligence. Finally, we propose a framework to fast track the immersion of advanced technologies into the high-containment research setting to improve global preparedness for new emerging diseases.
ISSN:1940-6029
DOI:10.1007/978-1-0716-3738-8_20