In vivo assessment of mitochondrial oxygen consumption

The protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) has been proposed by us as a potential clinical noninvasive tool for monitoring mitochondrial function. We have been working on the development of mitochondrial respirometry for monitoring mitochondrial oxygen tension (mitoPO2) and m...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1264; p. 219
Main Authors Harms, Floor A, Mik, Egbert G
Format Journal Article
LanguageEnglish
Published United States 2015
Subjects
Animals
In Vitro Techniques - instrumentation
In Vitro Techniques - methods
Luminescent Measurements - instrumentation
Luminescent Measurements - methods
Mitochondria - metabolism
Oxygen Consumption
Rats
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Summary:The protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) has been proposed by us as a potential clinical noninvasive tool for monitoring mitochondrial function. We have been working on the development of mitochondrial respirometry for monitoring mitochondrial oxygen tension (mitoPO2) and mitochondrial oxygen consumption (mitoVO2) in skin. In this work we describe the principles of the method in experimental animals.
ISSN:1940-6029
DOI:10.1007/978-1-4939-2257-4_20