D2R striatopallidal neurons inhibit both locomotor and drug reward processes

The striatum contains two distinct types of GABAergic neurons, striatonigral and striatopallidal cells. Durieux and colleagues genetically ablated the striatopallidal population in mice, uncovering specific roles for these neurons in the control of locomotion and the response to the addictive drug a...

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Published inNature neuroscience Vol. 12; no. 4; pp. 393 - 395
Main Authors Durieux, Pierre F, Bearzatto, Bertrand, Guiducci, Stefania, Buch, Thorsten, Waisman, Ari, Zoli, Michele, Schiffmann, Serge N, de Kerchove d'Exaerde, Alban
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2009
Nature Publishing Group
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Summary:The striatum contains two distinct types of GABAergic neurons, striatonigral and striatopallidal cells. Durieux and colleagues genetically ablated the striatopallidal population in mice, uncovering specific roles for these neurons in the control of locomotion and the response to the addictive drug amphetamine. The specific functions of dopamine D 2 receptor–positive (D 2 R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D 2 R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D 2 R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
ISSN:1097-6256
1546-1726
DOI:10.1038/nn.2286