Neuroendocrine Carcinoma of Uterine Cervix: Stereotactic Radiotherapy for Brain Metastasis and Stereotactic Body Radiotherapy for Renal and Pancreatic Metastases

A case of cervical neuroendocrine carcinoma (NEC) of the uterine cervix (NECUC) was presented. After total hysterectomy with bilateral salpingo-oophorectomy and adjuvant chemotherapy, a left renal tumor and a pancreatic lesion developed and were both diagnosed on pathological examination as metastas...

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Published inCurēus (Palo Alto, CA) Vol. 12; no. 6
Main Authors Mori, Yoshimasa, Kida, Yoshihisa, Matsushita, Yasuhiro, Mizumatsu, Shinichiro, Hatano, Manabu, Morita, Noriko, Tsuzuki, Toyonori
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 27.06.2020
Cureus
Subjects
Biopsy
Brain cancer
Cancer therapies
Case reports
Cervix
Chemotherapy
Cytotoxicity
Hysterectomy
Kidney cancer
Lung cancer
Lymphatic system
Magnetic resonance imaging
Metastasis
Obstetrics/Gynecology
Oncology
Oophorectomy
Pancreas
Radiation Oncology
Radiation therapy
Surgery
Tumors
Work stations
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Summary:A case of cervical neuroendocrine carcinoma (NEC) of the uterine cervix (NECUC) was presented. After total hysterectomy with bilateral salpingo-oophorectomy and adjuvant chemotherapy, a left renal tumor and a pancreatic lesion developed and were both diagnosed on pathological examination as metastases from NEC. In addition, a brainstem metastasis causing neurologic signs developed. The brain lesion was treated by stereotactic radiotherapy (SRT) and the renal and pancreatic lesions by stereotactic body radiotherapy (SBRT). Despite control of the renal and pancreatic lesions, multiple small lung metastases developed later. Recurrence and newly developed brain metastases were treated by repeat stereotactic radiosurgery (SRS)/SRT successfully. Chemotherapy was continued and controlled the lung metastases until three and a half years after the initial operation of the uterus.
ISSN:2168-8184
DOI:10.7759/cureus.8869