Elevated maternal serum alpha-fetoprotein with oligohydramnios: ultrasound evaluation and outcome

Nineteen pregnancies evaluated for elevated maternal serum alpha-fetoprotein levels were found to have moderate to severe oligohydramnios. There were no survivors among six fetuses with ultrasound-diagnosed urinary tract anomalies. We followed 11 of the remaining 13 pregnancies with serial ultrasoun...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 72; no. 3 Pt 1; p. 337
Main Authors Richards, D S, Seeds, J W, Katz, V L, Lingley, L H, Albright, S G, Cefalo, R C
Format Journal Article
LanguageEnglish
Published United States 01.09.1988
Subjects
Abortion, Induced
alpha-Fetoproteins - analysis
Amniotic Fluid - analysis
Evaluation Studies as Topic
Female
Fetal Diseases - blood
Fetal Diseases - diagnosis
Humans
Kidney - abnormalities
Pregnancy
Pregnancy Outcome - blood
Pregnancy Trimester, Second
Prenatal Diagnosis
Prognosis
Retrospective Studies
Risk Factors
Ultrasonography
Urethral Obstruction - blood
Urethral Obstruction - diagnosis
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Summary:Nineteen pregnancies evaluated for elevated maternal serum alpha-fetoprotein levels were found to have moderate to severe oligohydramnios. There were no survivors among six fetuses with ultrasound-diagnosed urinary tract anomalies. We followed 11 of the remaining 13 pregnancies with serial ultrasound examinations. When the second ultrasound examination demonstrated severely decreased amniotic fluid, the outcome was always poor (intrauterine death, perinatal death, or fetal deformations). Of the five cases in which the second ultrasound showed normal to moderately decreased fluid, there were four surviving infants. When no primary malformations are seen on the initial ultrasound examination, serial ultrasound evaluations of amniotic fluid volume help predict the pregnancy outcome.
ISSN:0029-7844