Linkage group V of platyfishes and Swordtails of the genus Xiphophorus (Poeciliidae): linkage of loci for malate dehydrogenase-2 and esterase-1 and esterase-4 with a gene controlling the severity of hybrid melanomas

Electrophoretic variations ascribable to three enzyme loci coding for esterase-1 and -4 (ES1 and ES4) and a malate dehydrogenase-2 isozyme (MDH2) were studied in interspecific backcrosses of fishes of the genus Xiphophorus (Poeciliidae). Normal segregation was demonstrated for all three loci. Linkag...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 71; no. 4; p. 809
Main Authors Morizot, D C, Siciliano, M J
Format Journal Article
LanguageEnglish
Published United States 01.10.1983
Subjects
Animals
Carboxylesterase
Carboxylic Ester Hydrolases - genetics
Carboxylic Ester Hydrolases - isolation & purification
Crosses, Genetic
Electrophoresis, Starch Gel
Female
Fish Diseases - genetics
Fishes - genetics
Genetic Linkage
Humans
Malate Dehydrogenase - genetics
Malate Dehydrogenase - isolation & purification
Male
Melanoma - veterinary
Phenotype
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Summary:Electrophoretic variations ascribable to three enzyme loci coding for esterase-1 and -4 (ES1 and ES4) and a malate dehydrogenase-2 isozyme (MDH2) were studied in interspecific backcrosses of fishes of the genus Xiphophorus (Poeciliidae). Normal segregation was demonstrated for all three loci. Linkage analyses indicated a gene order of ES1-6%-ES4-33%-MDH2. This group [designated linkage group (LG) V] was shown to assort independently from the 11 loci comprising LG's I-IV and from 18 other informative markers, with the limits of the data. A factor controlling the extent of development of inherited melanomas was demonstrated to be associated only with LG V loci, implying predominant control by a single gene, which probably determines the completeness of differentiation of macromelanophores in hybrids. Possible explanations for variability in the apparent chromosomal position of the melanoma severity gene, as assessed by estimates of recombination with the LG V enzyme loci, are discussed.
ISSN:0027-8874