Radioimmunoassay typing gives a more precise definition of the HLA association of type 1 (insulin-dependent) diabetes

The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQw1, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest t...

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Published inDiabetologia Vol. 29; no. 7; p. 430
Main Authors Tosi, R, Vela, M, Adorno, D, Longo, A, Papola, F, Maccarone, D, Centis, D, Tanigaki, N, Raponi, M P, Candela, A
Format Journal Article
LanguageEnglish
Published Germany 01.07.1986
Subjects
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Female
Genotype
Histocompatibility Antigens Class II - analysis
Histocompatibility Antigens Class II - genetics
HLA-DR Antigens
Humans
Male
Polymorphism, Genetic
Radioimmunoassay
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Summary:The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQw1, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.
ISSN:0012-186X
DOI:10.1007/BF00506534