Effect of potassium, angiotensin II and ACTH on blood aldosterone and cortisol in sheep on different dietary potassium and sodium intakes

The short term aldosterone response to manipulations of potassium (K), angiotensin II (AII) and ACTH were examined in sheep on a variety of chronic electrolyte regimes. Reduction in Na intake increased blood aldosterone to a greater extent on 100 mmol/day K than a K-free diet. Aldosterone increased...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 11; no. 1; p. 97
Main Authors Humphery, T J, Coghlan, J P, Denton, D A, Fan, J S, Scoggins, B A, Stewart, K W, Whitworth, J A
Format Journal Article
LanguageEnglish
Published Australia 01.01.1984
Subjects
Adrenocorticotropic Hormone - pharmacology
Aldosterone - blood
Angiotensin II - pharmacology
Animals
Diet
Female
Hydrocortisone - blood
Potassium - pharmacology
Potassium Chloride - pharmacology
Sheep
Sodium - pharmacology
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Summary:The short term aldosterone response to manipulations of potassium (K), angiotensin II (AII) and ACTH were examined in sheep on a variety of chronic electrolyte regimes. Reduction in Na intake increased blood aldosterone to a greater extent on 100 mmol/day K than a K-free diet. Aldosterone increased in response to AII under conditions of chronic dietary Na restriction, in contrast to acute Na depletion. The effects of K, AII, and ACTH on aldosterone concentrations in sheep on varying intakes of Na and K are similar to that reported for other species.
ISSN:0305-1870
DOI:10.1111/j.1440-1681.1984.tb00245.x