Prevention of gallstone recurrence by non-steroidal anti-inflammatory drugs

In laboratory animals, non-steroidal anti-inflammatory drugs (NSAIDs) are reported to inhibit diet-induced gallstone formation. To see if these drugs had a similar effect in man, 82 patients who had taken part in a comparison of ursodeoxycholic acid, placebo, and diet for prevention of gallstone rec...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 2; no. 8622; p. 1223
Main Authors Hood, K, Gleeson, D, Ruppin, D C, Dowling, R H
Format Journal Article
LanguageEnglish
Published England 26.11.1988
Subjects
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin - therapeutic use
Cholelithiasis - prevention & control
Drug Evaluation
Female
Humans
Male
Middle Aged
Random Allocation
Recurrence
Retrospective Studies
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Summary:In laboratory animals, non-steroidal anti-inflammatory drugs (NSAIDs) are reported to inhibit diet-induced gallstone formation. To see if these drugs had a similar effect in man, 82 patients who had taken part in a comparison of ursodeoxycholic acid, placebo, and diet for prevention of gallstone recurrence were sent questionnaires about their use of NSAIDs during the period of the trial. 75 replied. After a mean follow-up of 33 (SEM 4) months none of the 12 regular users of NSAIDs had had gallstone recurrences, compared with 20 of the 63 who never or rarely used these drugs (p less than 0.02).
ISSN:0140-6736