TRPM8

Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. In this chapter we provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and (patho)physiolog...

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Bibliographic Details
Published inHandbook of experimental pharmacology no. 179; p. 329
Main Authors Voets, T, Owsianik, G, Nilius, B
Format Journal Article
LanguageEnglish
Published Germany 2007
Subjects
Animals
Calcium - metabolism
Gene Expression Regulation
Humans
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Neoplasms - genetics
Neoplasms - pathology
Thermosensing - genetics
Thermosensing - physiology
TRPM Cation Channels - agonists
TRPM Cation Channels - antagonists & inhibitors
TRPM Cation Channels - genetics
TRPM Cation Channels - physiology
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Summary:Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. In this chapter we provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and (patho)physiology of this TRP channel.
ISSN:0171-2004
DOI:10.1007/978-3-540-34891-7_20