Genetic analysis of B cell signaling

Recent evidence indicates that B lymphocytes are instructed continuously by B cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development and humoral immune responses, reinforcing the importance of studies of the BCR signals. One of the best cell l...

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Bibliographic Details
Published inSub-cellular biochemistry Vol. 40; p. 145
Main Authors Shinohara, Hisaaki, Kurosaki, Tomohiro
Format Journal Article
LanguageEnglish
Published United States 2006
Subjects
Animals
B-Lymphocytes - cytology
B-Lymphocytes - metabolism
Calcium - metabolism
Chickens
Enzyme Activation
Lipid Metabolism
NF-kappa B - metabolism
NFATC Transcription Factors - metabolism
Protein-Tyrosine Kinases - metabolism
Receptors, Antigen, B-Cell - metabolism
Recombination, Genetic
Signal Transduction - genetics
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Summary:Recent evidence indicates that B lymphocytes are instructed continuously by B cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development and humoral immune responses, reinforcing the importance of studies of the BCR signals. One of the best cell lines for these studies is a chicken DT40 B-cell line, because a high propensity of homologous recombination in this cell line allows us to easily take both genetic and biochemical approaches. Here, based upon the recent data, mainly obtained from the DT40 system, we discuss several new aspects on mechanisms by which BCR signals are propagated and modified.
ISSN:0306-0225
DOI:10.1007/978-1-4020-4896-8_10