Signal transduction in early heart development (I): cardiogenic induction and heart tube formation

Heart development begins with the induction of cardiogenic cells from the embryonic mesoderm, followed by the coalescing of these cells into a linear heart tube. Subsequent looping of the heart tube brings the rudimentary atria and ventricles into alignment for further development into the four-cham...

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Bibliographic Details
Published inExperimental biology and medicine (Maywood, N.J.) Vol. 232; no. 7; p. 852
Main Authors Wagner, Michael, Siddiqui, M A Q
Format Journal Article
LanguageEnglish
Published England 01.07.2007
Subjects
Animals
Cell Differentiation
Chick Embryo
Chickens
Ectoderm - metabolism
Embryonic Development
Gastrula
Gene Expression Regulation, Developmental
Heart - embryology
Humans
Models, Anatomic
Models, Biological
Organogenesis
Signal Transduction
Transforming Growth Factor beta - metabolism
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Summary:Heart development begins with the induction of cardiogenic cells from the embryonic mesoderm, followed by the coalescing of these cells into a linear heart tube. Subsequent looping of the heart tube brings the rudimentary atria and ventricles into alignment for further development into the four-chambered heart. Underlying these morphologic events is a complex program of signaling between cells and tissues that orchestrates their participation in heart development. Among these signals are bone morphogenetic proteins, fibroblast growth factors, Wnts, Hedgehog, and members of the transforming growth factor-beta family of signaling molecules. We review here the various properties of these signaling molecules and their signal transduction pathways in hopes of providing a greater appreciation of the molecular events driving heart development.
ISSN:1535-3702
DOI:10.3181/00379727-232-2320852