SAPHO syndrome or psoriatic arthritis? A familial case study

• Published in: Rheumatology (Oxford, England) Vol. 38; no. 5; pp. 463 - 467
• Main Authors: Dumolard, A, Gaudin, P, Juvin, R, Bost, M, Peoc'h, M, Phelip, X
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.05.1999
• Subjects: Acquired Hyperostosis Syndrome - diagnostic imaging; Acquired Hyperostosis Syndrome - genetics; Acquired Hyperostosis Syndrome - pathology; Arthritis, Psoriatic - diagnostic imaging; Arthritis, Psoriatic - genetics; Arthritis, Psoriatic - pathology; Cervical Vertebrae - diagnostic imaging; Cervical Vertebrae - pathology; Child; Diagnosis, Differential; Family Health; Female; Humans; Male; Nuclear Family; Osteomyelitis - diagnostic imaging; Osteomyelitis - genetics; Osteomyelitis - pathology; Radiography; Wrist Joint - diagnostic imaging; Wrist Joint - pathology
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/38.5.463

To discuss the relationships between SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome and the group of spondylarthropathies. Few reports of familial SAPHO have been published. We describe three children, two sisters and one brother, whose clinical and radiological presentation was in accordance with SAPHO syndrome. Two children developed psoriasis, and one child palmoplantar pustulosis. Both sacroiliac and sternoclavicular joints were involved in these three cases. Some features in our observations are also common to psoriatic arthritis. No association was found with HLA antigens, but a history of trauma preceding the onset of symptoms was present in all three children. We can consider that SAPHO is nosologically related to spondylarthropathies. Psoriatic arthritis could be the missing link between SAPHO and spondylarthropathies. It is likely that both genetic and environmental factors are involved.