Sex related differences in serum gastrin concentrations and G- and D-cell populations of the gastric mucosa in guinea-pigs (experimental RIA and immunocytochemical study)

In the present study antral G-cells which secrete gastrin and antral and fundic D-cells which secret somatostatin, an inhibitor of gastric acid secretion were revealed immunocytochemically and the population size estimated along with serum gastrin levels in ten male and eight female guinea pigs. Ser...

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Published inBritish journal of experimental pathology Vol. 67; no. 2; pp. 229 - 233
Main Authors KITTAS, C, XYNOS, E, NEONAKIS, E, FOUNTOS, A, ARONI, K, VASSILAKIS, S
Format Journal Article
LanguageEnglish
Published London Lewis 01.04.1986
Subjects
Animals
Applied sciences
Biological and medical sciences
Exact sciences and technology
Female
Fundamental and applied biological sciences. Psychology
Gastric Fundus - cytology
Gastric Mucosa - analysis
Gastric Mucosa - cytology
Gastrins - analysis
Gastrins - blood
Gastrointestinal hormones
Guinea Pigs
Immunoenzyme Techniques
Male
Other techniques and industries
Pyloric Antrum - cytology
Radioimmunoassay
Sex Factors
Somatostatin - analysis
Vertebrates: digestive system
Stomach
Vertebrata
Mammalia
Guinea pig
Gastrointestinal hormone
Digestive system
Immunocytochemistry
Mucosa
Rodentia
Gastrin
Peptide hormone
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Summary:In the present study antral G-cells which secrete gastrin and antral and fundic D-cells which secret somatostatin, an inhibitor of gastric acid secretion were revealed immunocytochemically and the population size estimated along with serum gastrin levels in ten male and eight female guinea pigs. Serum gastrin, antral G-cells, antral D-cells and fundic D-cells were 41.90 +/- 6.10 SD pg/ml, 210 +/- 18.03 SD cells/cm, 128.20 +/- 17.64 SD cells/cm and 121 +/- 17.91 SD cells/cm respectively in males and 35 +/- 4.62 SD pg/ml, 176 +/- 13.80 SD cells/cm, 108.40 +/- 6.90 SD cells/cm and 106.8 +/- 6.50 SD cells/cm respectively in females. The differences in serum gastrin levels, antral G-cell population and antral D-cell population between the two sexes were statistically significant (P less than 0.05, P less than 0.001, P less than 0.01). It is possible that endogenous androgens induce a relative hyperplasia and endogenous oestrogens a relative hypoplasia of G-cells. Antral D-cell differences may reflect an adaptive hormonal mechanism to the possible different states of gastric secretory functions.
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ISSN:0007-1021