Quality of Life Is Associated With Wearable-Based Physical Activity in Patients With Inflammatory Bowel Disease: A Prospective, Observational Study

• Published in: Clinical and translational gastroenterology Vol. 10; no. 11; p. e00094
• Main Authors: Wiestler, Miriam, Kockelmann, Fabian, Kück, Momme, Kerling, Arno, Tegtbur, Uwe, Manns, Michael P, Attaran-Bandarabadi, Masoumeh, Bachmann, Oliver
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.11.2019
• Subjects: Adult; Biomarkers - metabolism; C-Reactive Protein - metabolism; Cross-Sectional Studies; Exercise - physiology; Female; Follow-Up Studies; Humans; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - physiopathology; Inflammatory Bowel Diseases - rehabilitation; Leukocyte L1 Antigen Complex - metabolism; Male; Middle Aged; Patient Reported Outcome Measures; Prospective Studies; Quality of Life; Surveys and Questionnaires; Wearable Electronic Devices; Young Adult
• ISSN: 2155-384X
• DOI: 10.14309/ctg.0000000000000094

Patient-reported outcomes such as quality of life are gaining importance in the assessment of patients suffering from inflammatory bowel disease (IBD). The association of objectively measured physical activity and quality of life in patients with IBD has not been studied in depth. To investigate the association of disease-specific quality of life and physical activity as well as clinical and biochemical disease activity in patients with IBD. A total of 91 patients with IBD were stratified into 4 groups (Crohn's disease and ulcerative colitis, in remission and with moderate-severe activity, respectively) and evaluated in terms of disease-specific quality of life (Inflammatory Bowel Disease Questionnaire [IBDQ]), physical activity (accelerometry), body composition (bioelectrical impedance analysis), as well as clinical (Harvey-Bradshaw Index and Simple Clinical Colitis Activity Index) and biochemical (C-reactive protein and fecal calprotectin) parameters of disease activity. In patients with moderate-severe disease activity, the IBDQ was significantly lower as compared to patients in remission (Mann-Whitney U test and Kruskal-Wallis test, P < 0.001). The physical activity level was higher in remission than in active disease (Mann-Whitney U test, P < 0.05). The IBDQ was significantly correlated with the duration of strenuous physical activity per day (P = 0.029178, r = 0.235), skeletal muscle mass (P = 0.033829, r = 0.229), and biomarkers of inflammation (C-reactive protein: P < 0.005, r = -0.335 and fecal calprotectin: P < 0.005, r = -0.385). In this prospective, cross-sectional study, disease-specific quality of life was significantly associated with accelerometrically determined physical activity and disease activity in patients with IBD. This may be related to a reciprocal impact of these factors (DRKS00011370).