68Ga-DOTA-E-[c(RGDfK)]2 positron emission tomography–computed tomography in the evaluation of hepatic hemangioendothelioma epithelioid

Hemangioendothelioma epithelioid is a rare tumor that originates in soft tissues. Imaging evaluation with conventional modalities (tomography and magnetic resonance) is difficult. Novel radiotracers which capably evaluate angiogenesis may have a higher impact on the therapeutic decisions. A 45-year-...

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Bibliographic Details
Published inRare tumors Vol. 11
Main Authors Soldevilla-Gallardo, Irma, Medina-Ornelas, Sevastian S, Davanzo, Jenny, Pedrero-Piedras, Roberto
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 25.02.2019
Sage Publications Ltd
Subjects
Angiogenesis
Case Report
Computed tomography
Hepatectomy
Immunohistochemistry
Monoclonal antibodies
Positron emission tomography
Soft tissues
Thalidomide
Thrombosis
Tomography
68Ga-DOTA-E-[c(RGDfK)]2
hemangioendothelioma epithelioid
positron emission tomography
angiogenesis
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Summary:Hemangioendothelioma epithelioid is a rare tumor that originates in soft tissues. Imaging evaluation with conventional modalities (tomography and magnetic resonance) is difficult. Novel radiotracers which capably evaluate angiogenesis may have a higher impact on the therapeutic decisions. A 45-year-old man underwent workup for thrombosis and was diagnosed with hemangioendothelioma epithelioid based on the results of liver pathology and immunohistochemistry. The decision of the multidisciplinary board was to begin with thalidomide. After 4 months, progression of disease was documented and right hepatectomy was performed. A 68Ga-DOTA-E-[c(RGDfK)]2 positron emission tomography–computed tomography scan showed residual lesions. After documented angiogenesis by 68Ga-DOTA-E-[c(RGDfK)]2 positron emission tomography–computed tomography, nintedanib was administrated. And 1 year later, progression of the disease was documented by positron emission tomography–computed tomography. Ipilimumab plus nivolumab was started and partial response and excellent clinical response were documented. Molecular imaging with 68Ga-DOTA-E-[c(RGDfK)]2 positron emission tomography–computed tomography is a good biomarker of the response of hemangioendothelioma epithelioid, and ipilimumab plus nivolumab therapy demonstrated a good response.
ISSN:2036-3613
2036-3605
2036-3613
DOI:10.1177/2036361319831097