Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels

Calcium (Ca2+) ion microdomains are subcellular regions of high Ca2+ concentration that develop rapidly near open Ca2+ channels in the plasma membrane or internal stores and generate local regions of high Ca2+ concentration. These microdomains are remarkably versatile in that they activate a range o...

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Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 12; no. 7
Main Authors Barak, Pradeep, Parekh, Anant B
Format Journal Article
LanguageEnglish
Published Woodbury Cold Spring Harbor Laboratory Press 01.07.2020
Subjects
Ca2+-transporting ATPase
Calcium
Calcium channels
Calcium influx
Calcium ions
Calcium signalling
Channels
PERSPECTIVES
Signal transduction
Signaling
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Summary:Calcium (Ca2+) ion microdomains are subcellular regions of high Ca2+ concentration that develop rapidly near open Ca2+ channels in the plasma membrane or internal stores and generate local regions of high Ca2+ concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca2+ microdomains generated by store-operated calcium channels, a widespread and conserved Ca2+ entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca2+ microdomain can be influenced by Ca2+ ATPase pumps.
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ISSN:1943-0264
DOI:10.1101/cshperspect.a035097