Hapten and carrier specificities of cellular and humoral responses to highly substituted dinitrophenyl-human gamma-globulins in guinea-pigs

Delayed hypersensitivity (DH) and antibody reactions to the carrier and to the hapten have been studied in guinea-pigs immunized with different doses of highly substituted dinitrophenyl-human gamma-globulins (DNP56-HGG) in Freund's complete adjuvant (FCA). The results confirm that DH reactions...

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Bibliographic Details
Published inImmunology Vol. 29; no. 6; pp. 1145 - 1151
Main Authors Neveu, P J, Borduas, A G
Format Journal Article
LanguageEnglish
Published England 01.12.1975
Subjects
Anaphylaxis
Animals
Antibody Formation
Antibody Specificity
Arthus Reaction
Carrier Proteins - immunology
gamma-Globulins
Guinea Pigs
Haptens
Humans
Hypersensitivity, Delayed - immunology
Immunity, Cellular
Kinetics
Nitrobenzenes - immunology
Skin Tests
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Summary:Delayed hypersensitivity (DH) and antibody reactions to the carrier and to the hapten have been studied in guinea-pigs immunized with different doses of highly substituted dinitrophenyl-human gamma-globulins (DNP56-HGG) in Freund's complete adjuvant (FCA). The results confirm that DH reactions are specific for the carrier while antibody-mediated reactions are specific for the hapten in the early stages of the immune response. Later in the response, however, DH reactions to the hapten as well as a transient humoral reaction to the carrier could be observed. T cells specific for the hapten and B cells specific for the carrier are therefore triggered after a single infection of a highly substituted hapten-carrier conjugate in FCA. Their regulatory functions in the immune response to hapten-carrier conjugates are discussed.
ISSN:0019-2805
1365-2567