Asymmetric hydrogenation, transfer hydrogenation and hydrosilylation of ketones catalyzed by iron complexes

The conventional homogeneous catalysts for the enantioselective hydrogenation or transfer hydrogenation of ketones are based on platinum metals and, in particular, ruthenium. This method provides valuable enantiopure alcohols for the fine chemical industries. This tutorial review summarizes recent s...

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Bibliographic Details
Published inChemical Society reviews Vol. 38; no. 8; p. 2282
Main Author Morris, Robert H
Format Journal Article
LanguageEnglish
Published England 01.08.2009
Subjects
Catalysis
Hydrogenation
Iron - chemistry
Ketones - chemistry
Ruthenium - chemistry
Silanes - chemistry
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Summary:The conventional homogeneous catalysts for the enantioselective hydrogenation or transfer hydrogenation of ketones are based on platinum metals and, in particular, ruthenium. This method provides valuable enantiopure alcohols for the fine chemical industries. This tutorial review summarizes recent successes in replacing expensive and toxic ruthenium in these catalysts with "greener" iron substitutes including my lab's recent progress in this area using iron complexes containing readily-prepared tetradentate ligands. It will enlighten chemists interested in homogeneous catalysis and asymmetric synthesis.
ISSN:1460-4744
DOI:10.1039/b806837m