Combination chemotherapy resulting in complete response of huge lymph node metastases in undifferentiated gastric cancer--case report

A 67-year-old male was admitted to Kagoshima University Hospital and received distal gastrectomy with D1 lymph node dissection under the diagnosis of early gastric cancer. Five years later, a retroperitoneal tumor 12 cm in diameter was detected by abdominal CT. Although the tumor was curatively rese...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 37; no. 7; p. 1373
Main Authors Megumi, Koichi, Ishigami, Sumiya, Yanagita, Shigehiro, Arigami, Takaaki, Uenosono, Yoshikazu, Kurahara, Hiroshi, Maemura, Kosei, Shinchi, Hiroyuki, Hokita, Shuichi, Ueno, Shinichi, Natsugoe, Shoji
Format Journal Article
LanguageJapanese
Published Japan 01.07.2010
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cell Differentiation
Humans
Lymphatic Metastasis
Male
Positron-Emission Tomography
Remission Induction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Tomography, X-Ray Computed
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Summary:A 67-year-old male was admitted to Kagoshima University Hospital and received distal gastrectomy with D1 lymph node dissection under the diagnosis of early gastric cancer. Five years later, a retroperitoneal tumor 12 cm in diameter was detected by abdominal CT. Although the tumor was curatively resected, rapid recurrence was identified in the same retroperitoneal space. Chemoradiation therapy (radiation 50 Gy and bleomycin) for residual tumor was performed, but the tumor rapidly grew. The patient was given cisplatin (CDDP) and gemcitabine (GEM) following CPT-11 treatment. The recurred tumor was remarkably shrunken and completely regressed after eight courses of the chemotherapy. The retroperitoneal tumor was finally diagnosed as lymph node relapse from undifferentiated gastric cancer. This rare case of undifferentiated gastric cancer showed a complete lymph node response following combination chemotherapy of CDDP and GEM. Combination chemotherapeutic regime with CDDP and GEM seems to be useful for treatment of undifferentiated gastric cancer.
ISSN:0385-0684