Study on genotoxicity of aldicarb and methomyl

Genotoxicity of aldicarb and methomyl was explored. The aldicarb and methomyl were diluted by the deionized water respectively, and then five concentrations of aldicarb were generated as 0.002, 0.02, 0.2, 2, 20 microg/L, methomyl as 0.02, 0.2, 2, 20, 200 microg/L. The micronucleus of carp erythrocyt...

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Bibliographic Details
Published inHuanjing kexue Vol. 31; no. 12; p. 2973
Main Authors Sun, Xiao-Yu, Jin, Yong-Tang, Wu, Bin, Wang, Wei-Qin, Pang, Xiao-Lu, Wang, Jing
Format Journal Article
LanguageChinese
Published China 01.12.2010
Subjects
Aldicarb - toxicity
Animals
Bacteria - genetics
Carps - genetics
Comet Assay
DNA Damage - drug effects
Erythrocytes - drug effects
Humans
Insecticides - toxicity
Lymphocytes - drug effects
Methomyl - toxicity
Micronucleus Tests
Mutagenicity Tests
Mutation - drug effects
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Summary:Genotoxicity of aldicarb and methomyl was explored. The aldicarb and methomyl were diluted by the deionized water respectively, and then five concentrations of aldicarb were generated as 0.002, 0.02, 0.2, 2, 20 microg/L, methomyl as 0.02, 0.2, 2, 20, 200 microg/L. The micronucleus of carp erythrocyte was counted by micronucleus test. The mutation of bacteria was assessed by Ames test. The DNA damage of human lymphocytes was tested by comet assay. The genotoxicity of aldicarb and methomyl was estimated by the three toxicology tests mentioned above. The results showed that, in the micronucleus test, both any concentration of two pesticides were not able to induce higher frequency of micronucleus in carp erythrocyte (p > 0.05). Under condition of metabolic inactivation, although the number of colony with back mutation in any concentration of two pesticides did not exceed the double number of those with spontaneous mutation, the revertants of TA97 strains in the aldicarb 2-20 microg/L and the methomyl 20-200 micr
ISSN:0250-3301