SARS coronavirus and apoptosis

1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells. 2. Such apoptosis in Vero E6 cells is time- and dose-dependent. 3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) an...

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Published inHong Kong medical journal = Xianggang yi xue za zhi Vol. 14 Suppl 4; pp. 8 - 13
Main Authors Chow, K Y, Yeung, Y S, Hon, C C, Zeng, F, Law, K M, Leung, F C
Format Journal Article
LanguageEnglish
Published China 01.08.2008
Subjects
Adenoviridae - genetics
Adenoviridae - metabolism
Animals
Apoptosis - genetics
Apoptosis - physiology
Cell Death - genetics
Cell Proliferation
Cells, Cultured
Chlorocebus aethiops
Gene Expression Regulation, Viral
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Probability
SARS Virus - genetics
SARS Virus - physiology
Sensitivity and Specificity
Severe Acute Respiratory Syndrome - genetics
Severe Acute Respiratory Syndrome - virology
Spike Glycoprotein, Coronavirus
Transduction, Genetic
Vero Cells - cytology
Viral Envelope Proteins - genetics
Viral Envelope Proteins - metabolism
Viral Structural Proteins - genetics
Viral Structural Proteins - metabolism
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Summary:1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells. 2. Such apoptosis in Vero E6 cells is time- and dose-dependent. 3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1024-2708