Radiotherapy in the Management of Testicular Cancers

Testicular cancers are the most common solid malignancies affecting males between the ages of 15 and 35 years, although it accounts for only about 1% of all cancers in men. Approximately 95% of testicular tumors are germ cell tumors (GCT). At diagnosis, 1–2% of cases are bilateral and 80% of patient...

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Bibliographic Details
Published inPrinciples and Practice of Urooncology pp. 123 - 140
Main Authors Yildirim, Berna Akkus, Onal, Cem
Format Book Chapter
LanguageEnglish
Published Switzerland Springer International Publishing AG 2017
Springer International Publishing
Subjects
Non-seminoma
Oncology
Radiotherapy
Seminoma
Testicular tumors
Urology & urogenital medicine
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Summary:Testicular cancers are the most common solid malignancies affecting males between the ages of 15 and 35 years, although it accounts for only about 1% of all cancers in men. Approximately 95% of testicular tumors are germ cell tumors (GCT). At diagnosis, 1–2% of cases are bilateral and 80% of patients are diagnosed at stage I. The risk factors for testicular cancers are family history, cryptorchidism, altered hormonal environment, low fertility, abnormal sperm analysis, and immunosuppression. For treatment purposes, two broad categories are recognized: pure seminoma (no non-seminomatous elements present) and all others, which together are termed non-seminomatous germ cell tumors (NSGCT). Seminoma is highly sensitive to chemotherapy and radiotherapy (RT). The prognosis of patients is generally good; cure is an expected outcome in the majority of cases, even with metastatic disease.
ISBN:9783319561134
3319561138
DOI:10.1007/978-3-319-56114-1_7