Pilot investigation of the hydrating effects of topical acne medications

Topical therapies are effective in managing acne vulgaris but are associated with local adverse effects such as irritation and dryness. This 4-week pilot study compared skin hydration in 36 healthy adult women randomized to treatment with 1 of 4 topical therapies: 2 different (jar and tube) clindamy...

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Bibliographic Details
Published inJournal of drugs in dermatology Vol. 6; no. 8; p. 810
Main Authors Zhen, Yaxian, Stoudemayer, Marianne, Vamvakias, George, Kligman, Albert M
Format Journal Article
LanguageEnglish
Published United States 01.08.2007
Subjects
Administration, Cutaneous
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Infective Agents, Local - administration & dosage
Benzoyl Peroxide - administration & dosage
Clindamycin - administration & dosage
Dermatologic Agents - administration & dosage
Female
Gels
Humans
Middle Aged
Nonprescription Drugs - administration & dosage
Pilot Projects
Skin - drug effects
Skin - metabolism
Skin Physiological Phenomena - drug effects
Sulfacetamide - administration & dosage
Treatment Outcome
Water - metabolism
Water Loss, Insensible - drug effects
Water Loss, Insensible - physiology
Wettability - drug effects
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Summary:Topical therapies are effective in managing acne vulgaris but are associated with local adverse effects such as irritation and dryness. This 4-week pilot study compared skin hydration in 36 healthy adult women randomized to treatment with 1 of 4 topical therapies: 2 different (jar and tube) clindamycin 1%/benzoyl peroxide 5% gels, sodium sulfacetamide 10% lotion, or over-the-counter (OTC) moisturizing cream. Subjects treated with OTC moisturizer or sodium sulfacetamide exhibited decreased water loss, increased water retention, similar or improved levels of skin hydration, and decreased desorption rates. In contrast, subjects treated with jar or tube clindamycin/benzoyl peroxide had increased water loss, decreased water retention, decreased hydration, and increased desorption rates. Skin dryness decreased slightly in the moisturizer group. No serious adverse events occurred. Overall, the OTC moisturizer had the best skin hydration profile. Sodium sulfacetamide demonstrated some moisturizing characteristics, and no clinically relevant differences were noted between jar and tube clindamycin/benzoyl peroxide gels.
ISSN:1545-9616