Numerical simulation of fracture healing

• Published in: Sheng wu yi xue gong cheng xue za zhi Vol. 37; no. 5; pp. 930 - 935
• Main Authors: Fu, Ruisen, Yang, Haisheng
• Format: Journal Article
• Language: Chinese
• Published: China Sichuan Society for Biomedical Engineering 25.10.2020
• Subjects: Biological activity; Biological models (mathematics); Bone healing; Computer Simulation; Fracture Healing; Fractures, Bone; Fuzzy control; Fuzzy logic; Healing; Humans; Mathematical models; Mechanical properties; Mechanical stimuli; Models, Biological; Numerical methods; Numerical models; Simulation; Stress, Mechanical; Wound healing; mechanobiology; numerical model; fracture healing; tissue differentiation
• ISSN: 1001-5515
• DOI: 10.7507/1001-5515.202004010

Fracture is a common physical injury. Its healing process involves complex biological activities at tissue, cellular and molecular levels and is affected by mechanical and biological factors. Over recent years, numerical simulation methods have been widely used to explore the mechanisms of fracture healing, design fixators and develop novel treatment strategies, etc. This paper mainly recommend the numerical methods used for simulating fracture healing and their latest research progress, which helps people better understand the mechanism of fracture healing, and also provides direction and guidance for the numerical simulation research of fracture healing in the future. First, the fracture healing process and its relationship with mechanical stimulation and biological factors are described. Then, the numerical models used for simulating fracture healing (including mechano-regulatory model, biological regulatory model and mechano-biological regulatory model) and corresponding modeling techniques (mainly includ